<p>Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screenning for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.</p>
申请公布号
WO2005016342(A1)
申请公布日期
2005.02.24
申请号
WO2004US20902
申请日期
2004.06.30
申请人
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;SCHRAM, VERN, L.;SAUVE, ANTHONY, A.