发明名称 |
METHODS OF PRODUCING ANALGESIA AND ENHANCING OPIATE ANALGESIA |
摘要 |
Methods of producing analgesia and enhancing opiate analgesia are disclosed. The methods include administering a TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit vol- tage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega conopeptide MVIIA binding sites present in neuronal tissue. Also dis- closed is a novel omega conotoxin peptide derivative effective in producing analgesia.
|
申请公布号 |
CA2151741(A1) |
申请公布日期 |
1993.07.08 |
申请号 |
CA19922151741 |
申请日期 |
1992.12.30 |
申请人 |
NEUREX CORP |
发明人 |
JUSTICE ALAN;SINGH TEJINDER;GOHIL KISHOR CHANDRA;VALENTINO KAREN L;MILJANICH GEORGE |
分类号 |
A61K38/00;A61K38/17;C07K14/435;G01N33/94;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|