| 摘要 |
PCT No. PCT/EP93/02495 Sec. 371 Date May 9, 1995 Sec. 102(e) Date May 9, 1995 PCT Filed Sep. 15, 1993 PCT Pub. No. WO94/07449 PCT Pub. Date Apr. 14, 1994The invention provides a process for the production of transdermal therapeutic systems. A layer containing active substance is initially present as a tape or web in the form of a laminate, with a carrier layer and, possibly, further auxiliary layers and/or protective layers or the like. The active substance is then transferred from this layer, either by itself or in combination with at least one further layer, in sections, to the center of a second, wider web. The process is characterized by the fact that the tape or web (1) and the second web (2) are moved forward by steps, with different phases of motion and inoperative phases and/or different step lengths and/or differing speeds and that in the same appliance, during each inoperative or stationary phase of the webs (1, 2) the subdivision of the layer containing active substance and, as the case may be, of one or more further layers, with the exception of the carrier layer, takes place in phases and in the same forward direction, at right angles to the direction of web, into sections (7, 8) containing active substance of a size suitable for the user, and their transfer to the second web, the carrier sheet (9) being removed, in preferably equal intervals, using a transfer device which can be moved backwards and forwards in the direction of the web. |
