| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to new substituted 3-sulphur-indoles with formula I: or their pharmaceutically acceptable salts, or their solvates where: R1 represents NR4COR6, NHSO2R5, NHCOR6, 5-6-member heteroaryl, containing 1-2 heteroatoms, independently chosen from N, S and O; R2 represents H, C1-7alkyl; R3 represents quinolyl, phenyl, where the latter is substituted with a halogen, C1-6alkoxy, SO2R4; R4 represents C1-6alkyl; R5 and R6 independently represent C1-6alkyl, phenyl, imidazolyl, all of which can be substituted with NR14R15; R14, R15 each independently represents H, C1-C6alkyl; under the condition that, if R1 represents NHSO2R5, then R3 represents phenyl. ^ EFFECT: compounds can be used in making medicine for treating asthma, rhinitis or chronic obstructive pulmonary disease (COPD). ^ 10 cl, 37 ex |
