发明名称 |
Antisense microRNA and uses therefor |
摘要 |
Provided herein are methods to suppress specificity protein (Sp) activity in a cell associated with a cell proliferative disease. The methods are effective to inhibit a microRNA in the cell using an antisense microRNA oligonucleotide which results in an increase in expression of a specificity protein (Sp) suppressor gene thereby inducing Sp degradation, apoptosis or growth arrest by releasing inhibitors of G2/M (Myt-1) or inhibition. Also provided are methods of treating a cancer using the antisense microRNA oligonucleotide. In addition the present invention provides antisense microRNA-27a oligonucleotides useful in the methods described herein.
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申请公布号 |
US2009099123(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
US20080221266 |
申请日期 |
2008.08.01 |
申请人 |
SAFE STEPHEN H;CHINTHARLAPALLI SUDHAKAR;TALCOTT SUSANNE U |
发明人 |
SAFE STEPHEN H.;CHINTHARLAPALLI SUDHAKAR;TALCOTT SUSANNE U. |
分类号 |
A61K31/7105;C07H21/02;C12N15/113 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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