发明名称 |
IMMUNOGEN PRESENTING HIV GP120 V3 LOOP IN A CONFORMATION THAT INDUCES BROADLY NEUTRALIZING ANTIBODIES |
摘要 |
Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
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申请公布号 |
US2009098144(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
US20080195318 |
申请日期 |
2008.08.20 |
申请人 |
NEW YORK UNIVERSITY;MOLSOFT LLC;UNIVERSITY OF MASSACHUSETTS;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
ZOLLA-PAZNER SUSAN;GORNY MIROSLAW K.;CARDOZO TIMOTHY J.;KONG XIANG-PENG;ABAGYAN RUBEN;TOTROV MAXIM;LU SHAN;PINTER ABRAHAM |
分类号 |
A61K39/42;A61P31/18;C07K16/10 |
主分类号 |
A61K39/42 |
代理机构 |
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