发明名称 |
METHOD AND APPARATUS FOR ENHANCING THE INTEGRITY OF AN IMPLANTABLE SENSOR DEVICE |
摘要 |
A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication. |
申请公布号 |
EP1549209(A4) |
申请公布日期 |
2009.04.15 |
申请号 |
EP20030752358 |
申请日期 |
2003.09.15 |
申请人 |
MEDTRONIC MINIMED, INC. |
发明人 |
SHAH, RAJIV;ZHANG, YANAN;GOTTLIEB, REBECCA;REGHABI, BAHAR;MILLER, MICHAEL, E. |
分类号 |
A61B5/00;A61B5/05;C12Q1/00;G01N33/487 |
主分类号 |
A61B5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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