发明名称 |
TETRAHYDROPYRAN NUCLEIC ACID ANALOGS |
摘要 |
The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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申请公布号 |
US2009092981(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
US20080192847 |
申请日期 |
2008.08.15 |
申请人 |
SWAYZE ERIC E;SIWKOWSKI ANDREW M;BHAT BALKRISHEN;PRAKASH THAZHA P;ALLERSON CHARLES;SETH PUNIT P |
发明人 |
SWAYZE ERIC E.;SIWKOWSKI ANDREW M.;BHAT BALKRISHEN;PRAKASH THAZHA P.;ALLERSON CHARLES;SETH PUNIT P. |
分类号 |
A61K31/7105;C07H19/06;C07H19/16;C12N15/11;C12Q1/00 |
主分类号 |
A61K31/7105 |
代理机构 |
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地址 |
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