发明名称 |
ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A) |
摘要 |
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
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申请公布号 |
US2010310451(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
US20080740654 |
申请日期 |
2008.11.03 |
申请人 |
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN;IRCM (INSTITUT DE RECHERCHES CLINQUES DE MONTREAL);MOUNT SINAI SCHOOL OF MEDICINE |
发明人 |
MARET DEBORAH;COLMAN DAVID R.;GRUZGLIN EUGENIA;SEIDAH NABIL |
分类号 |
A61K51/00;A61K49/00;A61K49/06;C12Q1/68;G01N33/574 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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