AMINOQUINOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: A novel aminoquinoline compound or pharmaceutically acceptable salt thereof are provided to ensure anti-proliferative efficiency with respect to melanoma and to prevent or treat skin cancer. CONSTITUTION: An amino quinoline compound is denoted by chemical formula 1. A method for preparing the amino quinoline compound or pharmaceutically acceptable salt thereof comprises: a step of performing nitration of a compound of chemical formula 2 to obtain a compound of chemical formula 3; a step of substituting the compound of chemical formula 3 to amino phenol compound to obtain a compound of chemical formula 4; a step of coupling the compound of chemical formula 4 with carboxylic acid compound of general formula R^5-CO_2H or isocyanate of general formula R^5-NCO to obtain a compound of chemical formula 5; a step of reducing the compound of chemical formula 5 to obtain a compound of chemical formula 6; a step of performing amidation of the compound of chemical formula 6 with carboxylic acid of general formula R^4-CO_2H. A pharmaceutical composition for preventing or treating skin cancer contains aminoquinoline compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.