发明名称 |
COMBINATION THERAPY FOR TREATING HCV INFECTION IN SPECIFIC PATIENT SUBGENOTYPE SUB-POPULATION |
摘要 |
The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin. Compound (1) is a selective and potent inhibitor of the HCV NS3 serine protease. The present invention also relates to methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in patients having genetic variations located near the IL28B gene, including SNP rs12979860 with a non-CC genotype and SNP rs8099917 with a non-TT genotype. |
申请公布号 |
WO2013144193(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013EP56499 |
申请日期 |
2013.03.27 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BOECHER, WULF OTTO;NEHMIZ, GERHARD;SAUTER, WIEBKE;STEINMANN, GERHARD G.;ZIMDAHL-GELLING, HEIKE |
分类号 |
A61K31/4709;A61K31/7056;A61K38/21;A61P31/14;C12Q1/68 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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