发明名称 |
Method and Kit for Evaluating and Monitoring a Treatment Program for Anemia |
摘要 |
The present disclosure relates to methods and kits for evaluating and/or monitoring a treatment program, such as in an anemic subject or in a subject receiving treatment for anemia, including determining a presence or an amount of growth differentiation factor 15 (GDF15) and/or hepcidin in a biological sample from the subject. Further, in some embodiments, the disclosure provides methods and/or kits for treating a disorder of iron homeostasis in a subject, comprising measuring an amount of GDF15 and/or an amount of hepcidin in a sample from a subject and administering iron and/or erythropoietin (EPO) to the subject if there is a measurable difference in the amount of GDF15 and/or hepcidin in the sample as compared to a reference amount. |
申请公布号 |
US2015164991(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
US201414531999 |
申请日期 |
2014.11.03 |
申请人 |
Vanderbilt University |
发明人 |
Haase Volker H.;Liu Qingdu |
分类号 |
A61K38/18;A61K33/26 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
1. A method for treating a disorder of iron homeostasis in a subject, comprising:
providing a biological sample from the subject; determining an amount of growth differentiation factor 15 (GDF15) in the sample; comparing the amount of the GDF15 to a reference amount of GDF15; and administering to the subject an effective amount of at least one of iron and erythropoietin (EPO) if there is a measurable difference in the amount of GDF15 in the sample as compared to the reference amount of GDF15. |
地址 |
Nashville TN US |