| 摘要 |
<p>The disclosure relates to an amphiphilic pressure sensitive adhesive composition suitable for securing a medical device to human skin, wherein the pressure sensitive adhesive comprises a copolymer of at least one hydrophobic acrylic monomer or oligomer; at least one hydrophilic or amphiphilic monomer or oligomer; and a crosslinker; wherein the hydrophobic monomer or oligomer is a long chain acrylate selected from butyl acrylate, iso-octyl acrylate, n-octyl acrylate, 2-ethylhexyl acrylate, and combinations thereof; the hydrophilic or amphiphilic monomer or oligomer is selected from acrylamides, N-alkylacrylamides, N,N-dialkylacrylamides, N-alkylaminoalkylacrylamides, methacrylamides, amino methacrylates, N-alkylamino acrylates, N,N-dialkylamino acrylates, N-alkylamino methacrylates, acrylamido alkylsulfonic acid and its salts, Nvinylpyrrolidones, N-vinylcaprolactams, and combinations thereof; and the crosslinker is selected from polybutadiene dimethacrylate, trimethylolpropane trimethacrylate, and ethylene glycol dimethacrylate; such that the amphiphilic copolymer: a) is crosslinked with a chemical crosslinker, b) does not dissolve in aqueous medium, c) absorbs less than 10% of its weight in the presence of water or moisture, d) is peelable from human skin and does not leave residue, e) remains adherent to skin under wet conditions, and f) has a glass transition temperature below 25°C. The disclosure also relates to a composition where the medical device is an ostomy appliance, wound dressing, surgical device, catheter, intravenous delivery device, or infusion device.</p> |
