| 发明名称 |
Benzo[f][1,4]oxazepine-5-one derivatives as ion channel modulators |
| 摘要 |
The present invention relates to new compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.The structure of the claimed compounds is given by Formula II:wherein R2, R3, R4, R10, R17, m and n are as defined in the description.The compounds function as late current sodium channel blockers. |
| 申请公布号 |
MD4371(B1) |
申请公布日期 |
2015.09.30 |
| 申请号 |
MD20130000095 |
申请日期 |
2012.06.29 |
| 申请人 |
GILEAD SCIENCES, INC. |
发明人 |
CORKEY BRITTON KENNETH;ELZEIN ELFATIH;JIANG ROBERT H.;KALLA RAO V.;KOLTUN DMITRY;LI, XIAOFEN;MARTINEZ RUBEN;PARKHILL ERIC Q.;PERRY THAO;ZABLOCKI, JEFF;VENKATARAMANI, CHANDRASEKAR;GRAUPE, MICHAEL;GUERRERO JUAN |
| 分类号 |
C07D243/24;A61K31/5513;A61K31/553;A61K31/554;A61P5/48;A61P9/00;A61P25/00;A61P25/02;C07D267/14;C07D291/08;C07D403/06;C07D413/12;C07D413/14;C07D419/06;C07D471/04;C07D487/04;C07D498/04 |
主分类号 |
C07D243/24 |
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