| 摘要 |
Disclosed are immunotherapeutic compositions comprising: a) a yeast vehicle; and b) a cancer antigen comprising at least one Brachyury antigen, wherein the Brachyury antigen comprises SEQ ID NO:6, positions 2-435 of SEQ ID NO:6, SEQ ID NO:18, positions 2-435 of SEQ ID NO:18, or an amino acid sequence that is at least 95% identical to SEQ ID NO:18 and comprises a substitution of a leucine at position 254 with a valine, wherein the sequences are as defined in the complete specification. Also disclosed is use the composition in treating, delaying onset of, or preventing cancer. |
