| 发明名称 | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators | ||
| 摘要 | Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | ||
| 申请公布号 | US9139564(B2) | 申请公布日期 | 2015.09.22 |
| 申请号 | US201214368064 | 申请日期 | 2012.12.26 |
| 申请人 | IRONWOOD PHARMACEUTICALS, INC. | 发明人 | Kim Charles;Nakai Takashi;Moore Joel;Perl Nicholas Robert;Im G-yoon Jamie;Barden Timothy Claude;Iyengar Rajesh R.;Zimmer Daniel P.;Fretzen Angelika;Renhowe Paul Allan |
| 分类号 | A61K31/506;C07D403/04;C07D413/14;C07D417/14;A61K31/4439;A61K31/513;A61K31/519;A61K31/52;A61K45/06;C07D473/00;C07D487/04;C07D513/22 | 主分类号 | A61K31/506 |
| 代理机构 | Heslin Rothenberg Farley & Mesiti, P.C. | 代理人 | Heslin Rothenberg Farley & Mesiti, P.C. |
| 主权项 | 1. A compound depicted below, or a pharmaceutically acceptable salt thereof: | ||
| 地址 | Cambridge MA US | ||