| 发明名称 |
Hydrophilic polymeric particles and methods for making and using same |
| 摘要 |
A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle. |
| 申请公布号 |
US9139666(B2) |
申请公布日期 |
2015.09.22 |
| 申请号 |
US201314082368 |
申请日期 |
2013.11.18 |
| 申请人 |
Life Technologies Corporation;Life Technologies AS |
发明人 |
Fonnum Geir;Modahl Grete I.;Kjus Nini H.;Molteberg Astrid E.;Tran Diem;Aaserud Jo;Gokmen Talha M.;Menchen Steven M.;Fuller Carl;Andruzzi Luisa;Hinz Wolfgang |
| 分类号 |
C12Q1/68;C08F8/34;C07F7/18;C08F6/24;C08F130/08;C08F2/20;C08F2/26;C08F220/58;C08F230/08;C08F222/38;C08F8/32 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of forming a particle, the method comprising:
polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups; removing at least a portion of plurality of the hydrophobic protection groups from the polymeric particle to form a hydrophilic particle; and binding an oligonucleotide to the hydrophilic particle. |
| 地址 |
Carlsbad CA US |
