| 发明名称 | ACTRIIB-FC polynucleotides, polypeptides, and compositions | ||
| 摘要 | In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRII protein and/or an ActRII ligand. | ||
| 申请公布号 | US9138459(B2) | 申请公布日期 | 2015.09.22 |
| 申请号 | US201213588468 | 申请日期 | 2012.08.17 |
| 申请人 | Acceleron Pharma Inc. | 发明人 | Knopf John;Seehra Jasbir |
| 分类号 | C07K1/00;A61K38/17;A61K9/20;C07K14/705 | 主分类号 | C07K1/00 |
| 代理机构 | Ropes & Gray LLP | 代理人 | Ropes & Gray LLP |
| 主权项 | 1. A polypeptide comprising an extracellular domain of an ActRIIA polypeptide, a linker domain having the sequence TGGG (SEQ ID NO:21), and an immunoglobulin Fc domain, wherein the extracellular domain comprises an amino acid sequence that is at least 97% identical to SEQ ID NO: 1, and wherein the immunoglobulin Fc domain is fused to the extracellular domain of the ActRIIA polypeptide by the linker domain, and wherein the polypeptide comprises an amino acid mutation at position 164 with respect to the sequence of SEQ ID NO:1. | ||
| 地址 | Cambridge MA US | ||