PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT

摘要

It is intended to provide a novel preventive or remedy for keratoconjunctival disorders. An Nrf2 activator regulates the induction of the expression of genes of a phase II xenobiotic-metabolizing enzyme, an antioxidant enzyme and so on in corneal epithelial cells and thus exerts an excellent amelioration effect on a corneal disorder model. Therefore, it is useful as a preventive or remedy for keratoconjunctival disorders such as dry eye, punctate keratopathy, corneal epithelial defect, corneal erosion, corneal ulcer, conjunctival epithelial defect, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, filamentary keratoconjunctivitis, infectious keratitis, non-infectious keratitis, infectious conjunctivitis, non-infectious conjunctivitis and so on.