用于合成羧醯胺之方法;PROCESS FOR THE SYNTHESIS OF CARBOXAMIDES

摘要

本发明提供一种合成羧醯胺之方法，包含步骤：a)提供式RCOOR’之羧酸酯及氨(NH3)、b)混合化学式为RCOOR’之羧酸酯及氨(NH3)，及c)使式RCOOR’之羧酸酯与氨(NH3)进行反应以生成式RCONH2之羧醯胺及R’OH，其特征在于于步骤a)中该氨系以液态形式或超临界形式引入。本发明进一步提供用于实施本发明方法的设备。 The invention provides a process for the synthesis of carboxamides, comprising the steps: a) providing a carboxylate of the formula RCOOR’ and ammonia (NH3), b) mixing the carboxylate of the formula RCOOR’ and ammonia (NH3), and c) reacting the carboxylate of the formula RCOOR’