发明名称 |
IGF-1 FUSION POLYPEPTIDES AND THERAPEUTIC USES THEREOF |
摘要 |
<p>A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 variants were shown to have improved ability to induce skeletal muscle hypertrophy relative to native IGF1.</p> |
申请公布号 |
PT2241575(E) |
申请公布日期 |
2015.09.16 |
申请号 |
PT20060007017T |
申请日期 |
2006.01.06 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
GEORGE D. YANCOPOULOS;THOMAS J. DALY;NICHOLAS J. PAPADOPOULOS;DAVID J. GLASS |
分类号 |
C07K14/65;A61K38/00;A61K38/29;A61K38/30;A61P3/10;A61P21/00;C07K19/00 |
主分类号 |
C07K14/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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