Guanidinyl-substituted polyamides useful for treating human papilloma virus

摘要

Polyamide compositions containing guanidinyl radicals, including tetramethylguanidinyl radicals, are described. These polyamides are useful for medical applications, for example, for treating human papilloma virus infections.

主权项

1. A compound of the formula:
G-(X)n-γq-(X)m-A or a pharmaceutically acceptable salt thereof, wherein
m is 5-12;n is 4-10;G is a guanidinyl radical is the formula or its tautomer, wherein R1, R2, R3, or R4 is H, alkyl, aryl or aralkyl;
each X is independently selected from 4-amino-2-carbonyl-N-methylimidazole (Im), 4-amino-2-carbonyl-N-methylpyrrole (Py) or β-alanine (β); γq is γ-aminobutyric acid (γ), 2,4-diaminobutyric acid (γNH2), or H2N(CH2)2CH(NHC(═O)NHR)CO2H, wherein R is —(CH2)3—N(CH3)—(CH2)3—NH2 (γNHR′) or —(CH2)3—N(CH3)2 (γNHR″); and A is 3,3′-diamino-N-methyldipropylamine (Ta) or 3-(dimethylamino)propylamine (Dp).