| 摘要 |
Rel proteins as a novel therapeutic agent for treating bacterial threats. More specifically, a novel class of compounds of Formula (I) as disclosed herein which possess antibacterial activity and which inhibit RelA, RelSeq or RelSpo synthetic activity or bacterial spore formation. Also, pharmaceutical compositions of such compounds and a method of combating bacteria, or treating bacterial infections, by administering to a subject in need thereof such compounds or pharmaceutical compositions. |
| 主权项 |
1. A compound represented by the structure of formula (I): wherein: (a) X is (b) X is (c) X is R and R1 are each independently selected from the group consisting of: R2 is H or R3 and R5 are each independently H or a moiety selected from the group consisting of: R7, R8a, R8b, R9, R11 and R12 are each independently H, a C1-C6 alkyl, a C1-C6 alkylaryl, or an aryl; R6 and R10 are each independently a side chain of a natural or unnatural amino acid; n is 1, 2, 3, 4, 5 or 6; and m is 1 or 2;
including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, complexes and mixtures thereof. |
