Detection method

摘要

The object of the present invention is to provide a biomarker which is highly correlated to the conventional biomarkers of metabolic syndrome or life-style related disease in a wide range of subjects to be tested, including subjects of special health check-up aged between 40 and 74, or an advantageous method for detecting metabolic syndrome or life-style related disease. The object can be solved by a method for detecting metabolic syndrome or life-style related disease by measuring the concentration of choline plasmalogen in a sample to be tested.

主权项

1. A method for detecting a metabolic syndrome or a life-style related disease the method comprising:
(1) measuring a concentration of a choline plasmalogen in a human sample, wherein at least one compound selected from the group consisting of 1-alkenyl cyclic phosphatidic acid of the general formula (1): wherein R3 is an alkyl group having 4 to 26 carbon atoms or an alkenyl group having 4 to 26 carbon atoms, and M is a hydrogen atom or a counter cation, and a compound of the general formula (2): wherein R1 is an alkyl group having 7, 9, 11, 13, 15, 17, 19, or 21 carbon atoms, and R2 is an alkyl group having 8 to 21 carbon atoms or an alkenyl group having 8 to 21 carbon atoms, is used as an internal standard material for measuring the concentration of the choline plasmalogen, and (2) comparing the concentration of the choline plasmalogen measured in step (1) with a reference value of a normal human sample.