| 发明名称 |
COMPOSITIONS AND METHODS FOR IDENTIFYING B CELL MALIGNANCIES RESPONSIVE TO B CELL DEPLETING THERAPY |
| 摘要 |
The invention provides compositions and methods featuring the use of miR-629 for identifying subjects responsive to B-cell depleting therapies (e.g., treatment with an anti-CD19 antibody). In other embodiments, the invention features the use of miR-629 to identify subjects as having a B cell malignancy. |
| 申请公布号 |
US2015252431(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514638765 |
申请日期 |
2015.03.04 |
| 申请人 |
MEDLMMUNE, LLC |
发明人 |
YAO YIHONG;STREICHER KATIE;RANADE KOUSTUBH;BROHAWN PHILIP Z.;KUZIORA MICHAEL |
| 分类号 |
C12Q1/68;C07K16/30 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of selecting therapy for a subject having a B cell malignancy, the method comprising detecting decreased miR-629 expression in a blood sample of the subject relative to a reference level, wherein detection of said decrease selects the subject for anti-CD19 antibody therapy. |
| 地址 |
GAITHERSBURG MD US |
