Virus-based vaccine composition having a protein with zinc finger pattern(s), method of preparing and using same

摘要

Vaccine composition made of at least one virus strain exhibiting at least one protein having zinc finger motifs, comprises: virus in an inactivated state in which zinc was ejected from the protein by one redox reaction with azodicarbonamide, where the virus is entire and has a viral envelope intact after inactivation; biurea formed from azodicarbonamide during the redox reaction; and optionally an unreacted azodicarbonamide residue. An independent claim is included for preparing the vaccine composition, comprising: contacting the virus strain exhibiting the protein with micronized azodicarbonamide; penetrating micronized azodicarbonamide through the viral envelope of virus by leaving the envelope intact; and inactivating the virus by a redox reaction between micronized azodicarbonamide and the protein resulting by an ejection of the zinc from the protein and a partial decomposition of azodicarbonamide into biurea. ACTIVITY : Virucide. MECHANISM OF ACTION : Vaccine.