Small molecule inhibitors of Dusp6 and uses therefor

摘要

Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.

主权项

1. A compound having the formula: in which R1 represents one or more independently of H, halo, C1-3 alkyl, C1-3 alkoxyl or —CN; R2 is a secondary or tertiary amine group; R3 is one or more independently of halo, C1-3 alkyl, C1-3 alkoxyl or —CN; and R4 is ═O or OH, or a pharmaceutically acceptable salt thereof.