发明名称 |
Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
摘要 |
Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression and activity. The disclosed methods typically include administering to a patient in need thereof a proteasome inhibitor and administering to the patient in need thereof a glucocorticoid receptor (GR) agonist, either before, concurrently with, or after the proteasome inhibitor is administered. |
申请公布号 |
US9126997(B1) |
申请公布日期 |
2015.09.08 |
申请号 |
US201113226865 |
申请日期 |
2011.09.07 |
申请人 |
Northwestern University |
发明人 |
Budunova Irina;Yemelyanov Alexander |
分类号 |
C07D471/02;C07D271/00;A01N43/42 |
主分类号 |
C07D471/02 |
代理机构 |
Andrus Intellectual Property Law, LLP |
代理人 |
Andrus Intellectual Property Law, LLP |
主权项 |
1. A method of treating leukemia or myeloma comprising administering to a patient in need thereof a proteasome inhibitor and administering to the patient a glucocorticoid receptor (GR) agonist, wherein the proteasome inhibitor is administered before, concurrently with, or after the GR agonist is administered. |
地址 |
Evanston IL US |