发明名称 |
ALFA-GALACTOSYLCERAMIDANALOGER OG DERES ANVENDELSE SOM IMMUNTERAPIER, ADJUVANSER OG ANTIVIRALE, ANTIBAKTERIELLE OG ANTICANCER-MIDLER |
摘要 |
<p>The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.</p> |
申请公布号 |
DK2320947(T3) |
申请公布日期 |
2015.09.07 |
申请号 |
DK20090795269T |
申请日期 |
2009.07.10 |
申请人 |
ACADEMIA SINICA |
发明人 |
WONG, CHI-HUEY;YU, ALICE;LIN, KUN-HSIEN;CHENG, EDMOND Y.S.;JAN, JIA-TSRONG;LIN, YI-LING;HUNG, JUNG-TUNG;CHANG, YA-JEN |
分类号 |
C07H15/18;A61K31/70;A61K31/7034;A61K39/00;A61K39/39;A61P31/04;A61P31/16;A61P35/00 |
主分类号 |
C07H15/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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