PREPARATION OF AN INTERMEDIATE COMPOUND OF IOFORMINOL

摘要

The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. More particularly, the invention relates to a work-up process for preparation of a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene, a key intermediate in the process for preparing Ioforminol. Further, the invention relates to a process for preparing Ioforminol, a contrast agent useful in X-ray imaging.

主权项

1. A process for preparation of a compound mixture (3) as a powder Compound mixture 3wherein each X individually denotes hydrogen, a formyl group (—CO—H) or an acetyl group (—CO—CH3), said process comprising:
i) formylating the amino function of 5-amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (compound (4)); ii) performing a work-up procedure wherein a short chain alcohol is added to the product solution of step i).