| 发明名称 |
Live attenuated <i>bordetella </i>strains as a single dose vaccine against whooping cough |
| 摘要 |
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided. |
| 申请公布号 |
US9119804(B2) |
申请公布日期 |
2015.09.01 |
| 申请号 |
US200712224895 |
申请日期 |
2007.03.07 |
| 申请人 |
Institut Pasteur de Lille;Institut National de la Sante et da la Recherche Medicale |
发明人 |
Locht Camille;Mielcarek Nathalie;Debrie Anne-Sophie;Raze Dominique;Bertout Julie |
| 分类号 |
A01N63/00;A61K39/02;A61K39/00 |
主分类号 |
A01N63/00 |
| 代理机构 |
|
代理人 |
Kim Stanley A. |
| 主权项 |
1. A triple mutated Bordetella strain which is a BPZE1 strain deposited with the Collection Nationale de Culture Microorganismes (C.N.C.M.) on Mar. 9, 2006, under number 1-3585. |
| 地址 |
FR |
