| 发明名称 | Compositions and vaccines against influenza A and influenza B infections | ||
| 摘要 | Novel models of interactions of the Nonstructural Protein of influenza A and influenza B viruses (NS1A and NS1B, respectively) with dsRNA are presented. On the basis of the models, novel recombinant viruses and vaccines against influenza A and influenza B viruses are provided. | ||
| 申请公布号 | US9119810(B2) | 申请公布日期 | 2015.09.01 |
| 申请号 | US200612094114 | 申请日期 | 2006.11.17 |
| 申请人 | Rutgers, The State University of New Jersey | 发明人 | Montelione Gaetano T.;Krug Robert M.;Cuifeng Yin;Lichung Ma |
| 分类号 | A61K39/145;A61K39/00 | 主分类号 | A61K39/145 |
| 代理机构 | Fox Rothschild LLP | 代理人 | Fox Rothschild LLP ;Norton Gerard P.;Hao Jainming Jimmy |
| 主权项 | 1. An attenuated influenza B virus vaccine comprising eight viral RNA segments, wherein one segment of the RNA segments has a first mutation which causes a substitution of a first amino acid corresponding to an amino acid of SEQ. ID. NO. 2, a dsRNA binding domain of an NS1B protein, at a position 17, 43, 46, 57, or 61; and wherein said first mutation decreases the dsRNA binding ability of the NS1B protein. | ||
| 地址 | New Brunswick NJ US | ||