| 主权项 |
1. A compound of Formula IA, IB, IC or ID, or a pharmaceutically acceptable salt, ester or prodrug thereof: wherein each n and m is independently 0, 1, 2 or 3;
each p and q is independently 0, 1, 2, 3, 4, 5, 6 or 7;X1 is —C(O)N(RA)— or —C(S)N(RA)—;
wherein RA is independently hydrogen, aliphatic, substituted aliphatic, heteroaryl, substituted heteroaryl, aryl or substituted aryl;X2 is —S— —O—, —S(O)2— —C(R20)(R21)— or —N(RB)—;
wherein RB is independently hydrogen, aliphatic, substituted aliphatic, heteroaryl, substituted heteroaryl, aryl or substituted aryl;each R1 and R2 is independently hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl;R3 is hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl;each R10, and R28 is independently absent, hydrogen, halogen, —OR20, —SR20, —NR20R21, —CF3, —CN, —NO2, —N3, —C(O)OR20, —C(O)R20, —C(O)NR20R21, acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two of R10 groups together with the atoms to which they are attached and any intervening atoms may form an additional optionally substituted, 3, 4, 5, 6 or 7 membered ring;
wherein each R20 and R21 is independently hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl;each R11 is independently absent, hydrogen, halogen, —OR20, —SR20, —NR20R21, —CF3, —CN, —NO2, —N3, —C(O)R20, —C(O)OR20, —C(O)NR20R21, acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two of R11 groups together with the atoms to which they are attached and any intervening atoms may form an additional optionally substituted, 3, 4, 5, 6 or 7 membered ring;each G1 and G2 is independently, absent, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl;each R27 and R29 is independently hydrogen, alkyl, substituted alkyl, aryl or substituted aryl;wherein R3a is selected from alkyl, aryl, alkyl substituted with aryl, straight chain or branched C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkynyl, C1-C10 alkoxy, alkoxyC1-C10alkoxy, C1-C10alkylamino, alkoxyC1-C10alkylamino, C1-C10 alkylcarbonylamino, C1-C10 alkylaminocarbonyl, aryloxyC1-C10 alkoxy, aryloxyC1-C10alkylamino, aryloxyC1-C10 alkylamino carbonyl, C1-C10-alkylaminoalkylaminocarbonyl, C1-C10alkyl(N-alkyl)aminoalkyl-aminocarbonyl, alkylaminoalkylamino, alkylcarbonylaminoalkylamino, alkyl(N-alkyl)aminoalkylamino, (N-alkyl)alkylcarbonylaminoalkylamino, alkylaminoalkyl, alkylaminoalkylaminoalkyl, alkylpiperazinoalkyl, piperazinoalkyl, alkylpiperazino, alkenylaryloxyC1-C10 alkoxy, alkenylarylaminoC1-C10 alkoxy, alkenylaryllalkylamino C1-C10 alkoxy, alkenylaryloxyC1-C10 alkylamino, alkenylaryloxyC1-C10alkylaminocarbonyl, piperazinoalkylaryl, heteroarylC1-C10 alkyl, heteroarylC1-C10alkenyl, heteroarylC1-C10 alkynyl, heteroarylC1-C10 alkylamino, heteroarylC1-C10alkoxy, heteroaryloxyC1-C10alkyl, heteroaryloxyC1-C10 alkenyl, heteroaryloxyC2-C10 alkynyl, heteroaryloxyC1-C10alkylamino, and heteroaryloxyC1-C10 alkoxy; Cy1 is an optionally substituted aryl or optionally substituted heteroaryl; and, R40 is selected from:wherein, R41 is hydrogen, halogen, aliphatic, substituted aliphatic, aryl, substituted aryl, —OR20, —SR20, —NR20R21, —CF3, —CN, —NO2, —N3, —C(O)R20, —C(O)OR20, —C(O)NR20R21, acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl. |
