| 摘要 |
The present disclosure relates to pharmaceutical compositions comprising oxazolidinones. the pharmaceutical composition also comprises an emulsifier, and also a polymeric dissolution aid. These compositions are useful for treating microbial infections. The oxazolidinones, of the disclosure are: (S)-N-((3-(2-fluoro-4’-(((3-fluoropropyl)amino)methyl)-[1,1’-biphenyl]-4-yl)-2-oxooazolidin-5-y1)methyl)acetamide; (S)-N-((3-(2-fluoro-4’-(({ 3-fluoropropyl)(hydroxy)amino)metl7yl)-[1,1’-biphenyl]-4-y1)-2-oxooxazolidin-5-yl)methyl)acetamide; (S)-N-((3-(4’-((((1H-1,2,3-triazol-5-yl)methyl)amino)methyl)-2-fluoro-[1,1’-biphenyl]-4-yl)-2-oxooxazolidin-5-yl)methyl)acetamide; (R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(4’-((((1H-1,2,3-triazol-5-yl)methyl)amino)methyl)-2-fluoro-[1,1’-biphenyl]-4-yl)oxazolidin-2-one; (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide; and (S)-N-((3-(3-fluoro-4-(4-(2-hydroxyacetyl)piperarin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl} acetamide. |
