3-HYDROXYPROPIONIC ACID-PRODUCING RECOMBINANT MICROORGANISM AND METHOD OF PRODUCING 3-HYDROXYPROPIONIC ACID USING THE SAME

摘要

Disclosed is a method of producing 3-hydroxypropionic acid comprising the step of culturing recombinant microorganism comprising a nucleic acid sequence encoding Ilyobacter polytropus-derived glycerol dehydratase, and a nucleic acid sequence encoding dehydrogenase, which converts 3-hydroxypropionaldehyde into 3-hydroxypropionic acid, and a recombinant microorganism used therefor. According to the present invention, the production of 3-hydroxypropionic acid remarkably increases and the production amount of 1,3-propanediol (1,3-PDO), which is generated as by-products when producing 3-hydroxypropionic acid, remarkably decreases, compared to known recombinant microorganisms comprising gene expressing Klebsiella pneumonia-derived Vitamin B12-dependent glycerol dehydratase.

主权项

1. A method of producing 3-hydroxypropionic acid comprising culturing a recombinant microorganism comprising a nucleic acid encoding an Ilyobacter polytropus glycerol dehydratase, and a nucleic acid encoding 3-hydroxypropionaldehyde dehydrogenase, which converts 3-hydroxypropionaldehyde into 3-hydroxypropionic acid, with a carbon source to produce 3-hydroxypropionic acid.