| 发明名称 |
Connective tissue growth factor antisense oligonucleotides |
| 摘要 |
The present invention relates to antisense oligonucleotides that target human CTGF mRNA and inhibit CTGF mRNA expression. Additionally, regions of human CTGF mRNA that are exceptionally sensitive to antisense inhibition are disclosed. Pharmaceutical compositions comprising the antisense oligonucleotides are further disclosed. These compositions are useful for treating disorders and conditions that are associated with or influenced by CTGF expression. |
| 申请公布号 |
US9115356(B2) |
申请公布日期 |
2015.08.25 |
| 申请号 |
US201414201186 |
申请日期 |
2014.03.07 |
| 申请人 |
FIBROGEN, INC. |
发明人 |
Seeley Todd W.;Sternlicht Mark D. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A modified antisense oligonucleotide selected from the group consisting of SEQ ID NO:88, SEQ ID NO:203 and SEQ ID NO:262. |
| 地址 |
San Francisco CA US |
