发明名称 |
Anticuerpo dirigido contra el receptor EP4 de la prostaglandina E2 humano |
摘要 |
<p>It is an object of the present invention to provide an antibody that binds to a human PGE 2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE 2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.</p> |
申请公布号 |
ES2537017(T9) |
申请公布日期 |
2015.08.21 |
申请号 |
ES20110829187T |
申请日期 |
2011.09.28 |
申请人 |
NB HEALTH LABORATORY CO. LTD. |
发明人 |
TAKAYAMA, KIYOSHI;SHIMIZU, TOMOKO;URUSHIBATA, YUJI;SUGIMOTO, YUKIHIKO |
分类号 |
C12N15/09;A61K39/395;A61P29/00;A61P35/00;A61P37/02;C07K16/28;C07K17/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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