| 发明名称 |
PREPARATION OF 18F-FLUCICLOVINE |
| 摘要 |
The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis apparatus. |
| 申请公布号 |
US2015232415(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201314420493 |
申请日期 |
2013.08.07 |
| 申请人 |
GE Healthcare Limited |
发明人 |
Svadberg Anders;Ryan Olav;Smeets Roger |
| 分类号 |
C07C227/40;C07C227/16;B01J19/24;C07C227/18 |
主分类号 |
C07C227/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1) A method to prepare 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said method comprises:
(a) providing a compound of Formula II adsorbed to a solid phase: wherein:PG1 is a carboxy protecting group; and,PG2 is an amine protecting group; (b) reacting said adsorbed compound of Formula II with a PG1 deprotecting agent; (c) sending the PG1 deprotecting agent to waste following said reacting step (b); (d) passing an elution solution through said solid phase to obtain an eluted compound of Formula III: (e) reacting said eluted compound of Formula III obtained in step (d) with a PG2 deprotecting agent to obtain a reaction mixture comprising [18F]-FACBC. |
| 地址 |
Buckinghamshire GB |
