| 发明名称 |
ANTI-TUMOUR RESPONSE TO MODIFIED SELF-EPITOPES |
| 摘要 |
Anti-tumour immune responses to modified self-epitopes. The present invention relates to the use of tumour-associated epitopes in medicine and in particular in the treatment of cancer. The epitopes stimulate an immune reaction against the tumour and have a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. The invention also relates to nucleic acids comprising sequences that encode such epitopes for use in the treatment of cancer. |
| 申请公布号 |
US2015232525(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201514614964 |
申请日期 |
2015.02.05 |
| 申请人 |
Scancell Limited |
发明人 |
Durrant Linda Gillian;Brentville Victoria Anne;Metheringham Rachael Louise |
| 分类号 |
C07K14/47;G01N33/574;A61K39/00;C07K7/08;C07K7/06 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A tumour-associated epitope which stimulates an immune reaction against the tumour for use in medicine, the epitope having a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. |
| 地址 |
Nottingham GB |
