发明名称 |
Análogos cíclicos de peptídeo 4-amino-4-oxobutanoil inibidores de replicação viral |
摘要 |
<p>The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I and the pharmaceutically salts thereof. The variables are defined herein. Certain compounds of Formula I are useful as antiviral agents. 4-amino-4-oxobutanoyl peptide cyclic analogues as disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide cyclic analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptide cyclic analogue as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptide cyclic analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in patients.</p> |
申请公布号 |
BRPI0922913(A2) |
申请公布日期 |
2015.08.18 |
申请号 |
BR2009PI22913 |
申请日期 |
2009.12.10 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
AVINASH PHADKE;XIANGZHU WANG;GODWIN PAIS;AKIHIRO HASHIMOTO;VENKAT GADHACHANDA;DAWEI CHEN;ATUL AGARWAL;SUOMING ZHANG;CUIXIAN LIU;SHOUMING LI;MILIND DESHPANDE |
分类号 |
C07D403/14;C07D403/12;C07D417/14 |
主分类号 |
C07D403/14 |
代理机构 |
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地址 |
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