Machine for the manufacture of dosage forms utilizing radiofrequency energy

摘要

The present invention features the present invention features a machine for the production of a solid dosage form including: (a) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die platen, and a second opening at the surface on the opposite side of the die platen; (b) one or more first forming tools each adapted to move into one of the forming cavities through the first opening of the forming cavity; (c) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the forming cavities through the second opening of the forming cavity; (d) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (e) at least one second RF electrode operably associated with the one or more first forming tools.

主权项

1. A method of making a solid dosage form using a machine comprising:
(i) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of said die platen, and a second opening at the surface on the opposite side of said die platen; (ii) one or more first forming tools each adapted to move into one of said cavities through the first opening of said forming cavity; (iii) one or more second forming tools each adapted to move adjacent to one of said second openings or into one of said cavities through the second opening of said forming cavity; (iv) at least one first RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities; and (v) at least one second RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities; wherein said machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity, wherein said first RF electrode and said second RF electrode are arranged within said machine such that when RF energy is conducted between said first RF electrode and said second RF electrode, said RF energy passes through the portion of said forming cavity adapted to form said dosage form, and wherein said method comprises: (a) adding a powder blend to said forming cavity; (b) moving said first forming tool into said forming cavity through the first opening of said forming cavity such that said powder blend is formed into the shape of said dosage form within said forming cavity between said first forming tool and said second forming tool; (c) conducting RF energy between said first electrode and said second electrode such that said energy heats said powder blend within said forming cavity to form said dosage form; and (d) removing said dosage form from said forming cavity.