| 发明名称 |
METHOD OF TREATING LEUKEMIA |
| 摘要 |
The present invention relates to methods of treating disorders in which DOT1L-mediated protein methylation plays a part, such as cancer, by administering DOT1L inhibitor compounds and pharmaceutical compositions to subjects in need thereof. |
| 申请公布号 |
US2015216890(A1) |
申请公布日期 |
2015.08.06 |
| 申请号 |
US201314426331 |
申请日期 |
2013.09.06 |
| 申请人 |
Epizyme, Inc. |
发明人 |
Olhava Edward J.;Chesworth Richard;Kuntz Kevin W.;Richon Victoria M.;Pollock Roy M.;Daigle Scott Richard |
| 分类号 |
A61K31/7076 |
主分类号 |
A61K31/7076 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or its N-oxide or a pharmaceutically acceptable salt thereof: wherein the subject had at least one prior therapy to treat a hematological cancer. |
| 地址 |
Cambridge MA US |
