发明名称 |
Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
摘要 |
<p>The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.</p> |
申请公布号 |
AU2010351605(C1) |
申请公布日期 |
2015.08.06 |
申请号 |
AU20100351605 |
申请日期 |
2010.04.21 |
申请人 |
SIGNATURE THERAPEUTICS, INC. |
发明人 |
JENKINS, THOMAS E.;HUSFELD, CRAIG O.;SEROOGY, JULIE D.;WRAY, JONATHAN W. |
分类号 |
A01N43/42;A61K31/44 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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