Methods and Compositions for Modulating G-Alpha-Q Signaling

摘要

The present invention provides compositions and methods for modulating G-alpha-q activity and methods of screening of test substances for the ability to modulate G-alpha-q activity.

主权项

1. A method of downregulating G-alpha-Q signaling in a cell, comprising introducing into the cell a peptide comprising the amino acid sequence of Formula I:
X1 X2 X3 X4 X5 X6 X7 X8 X9 X10 X11 X12 X13 X14 X15 X16 X17 X18 X19 X20 X21,wherein
X1 is H; X2 is Q or any nonnatural amino acid or any amino acid listed in Table 2; X3 is D or any nonnatural amino acid or any amino acid listed in Table 2; X4 is Y; X5 is A; X6 is E or any nonnatural amino acid or any amino acid listed in Table 2; X7 is A; X8 is L or any nonnatural amino acid; X9 is I or A or Y or N or any nonnatural amino acid or any amino acid listed in Table 2; X10 is N; X11 is P; X12 is I; X13 is K or any nonnatural amino acid or any amino acid listed in Table 2; X14 is H; X15 is V; X16 is S; X17 is L or any nonnatural amino acid or any amino acid listed in Table 2; Xl8 is M or norleucine or any other nonnatural amino acid; X19 is D; X20 is Q; and X21 is R.