发明名称 |
REVERSE GENETICS OF NEGATIVE-STRAND RNA VIRUSES IN YEAST |
摘要 |
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA. |
申请公布号 |
US2015216962(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201514591459 |
申请日期 |
2015.01.07 |
申请人 |
Institut Pasteur ;Centre National De La Recherche Scientifique |
发明人 |
MILED Chaouki;TANGY Frédéric;JACOB Yves |
分类号 |
A61K39/165;C12N7/00;C07K14/005 |
主分类号 |
A61K39/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Paris FR |