发明名称 |
APPLICATION OF INULA LINEARIIFOLIA LACTONE A IN PREPARATION OF MEDICINE FOR TREATING MYOCARDITIS |
摘要 |
<p>Preparation and application of line leaf inula flower lactone A for treating myocarditis having a structure of
The compound shows positive therapeutic activity against Coxsackie virus and significant dose dependent correlation. The line leaf inula flower lactone A prevents disease in mouse models of experimental autoimmune myocarditis and onset of the process by intraperitoneal injection of a dose of 20 mg/kg/d. When increased to 100 mg/kg/d, the line leaf inula flower lactone A shows positive therapeutic effect on EAM. Line leaf inula flower lactone A is used as the sole active ingredient and combined with a conventional pharmaceutical carrier in a drug for treating myocarditis, and the pharmaceutical composition may be in the form of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol.</p> |
申请公布号 |
EP2865380(A4) |
申请公布日期 |
2015.08.05 |
申请号 |
EP20120879465 |
申请日期 |
2012.09.25 |
申请人 |
THE SECOND MILITARY MEDICAL UNIVERSITY |
发明人 |
ZHANG, WEIDONG;SHAN, LEI;JIN, HUIZI;SU, JUAN;LI, HUILIANG;SHEN, YUNHENG;XU, XIKE;LIU, RUNHUI |
分类号 |
A61K31/365;A61K9/08;A61K9/12;A61K9/14;A61K9/20;A61K9/22;A61K9/48;A61P9/00;A61P29/00;C07D307/93 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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地址 |
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