| 摘要 |
A compound that has the structure of Formula (XII):
wherein,
X 1 is CH, CR 3 or N;
X 2 is N, CH, or CR 3 ;
Z is -OH or -OR 10 ;
R 2 is C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 4 deuteroalkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 4 alkylene-W;
W is hydroxy, halogen, CN, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, and C 3 -C 6 cycloalkyl;
each R 3 is independently halogen, C 1 -C 4 alkyl, or C 1 -C 4 fluoroalkyl;
each R 4 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl;
each R 5 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl;
R 6 is H, C 1 -C 4 alkyl, or halogen;
R 7 is H, C 1 -C 4 alkyl, or halogen;
R 9 is H, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl;
R 10 is C 1 -C 6 alkyl;
m is 0, 1, or 2;
n is 0, 1, 2, 3, or 4; and
p is 0, 1, or 2;
or a pharmaceutically acceptable or N-oxide thereof. |
