发明名称 |
Virally-safe plasma-derived factor viii composition |
摘要 |
<p>Factor VIII composition (A) of plasma origin and free of virus is produced by filtration through a nanometer filter of nominal pore opening 15+-2 nm to 23+-2 nm and includes von Willebrand factor (vWF) with not over 15% in the form of decamers or higher multimers. Independent claims are also included for the following: (1) method for testing the viral security of a factor VIII composition of plasma origin, prepared by nanometer filtration, by determining the level of residual highly multimeric vWF; and (2) method for preparing (A) by filtration through a specified filter and determining the proportion of vWF present as decamers or higher multimers. ACTIVITY : Hemostatic. No biological data is given. MECHANISM OF ACTION : Protein replacement.</p> |
申请公布号 |
IL228278(A) |
申请公布日期 |
2015.07.30 |
申请号 |
IL20130228278 |
申请日期 |
2013.09.03 |
申请人 |
LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES |
发明人 |
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分类号 |
A61K;A61K38/00;A61K38/37;A61L2/00;A61P7/04;C07K;C07K1/34;C07K14/755;C12Q1/04;C12Q1/56;G01N33/68;G01N33/86 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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