| 发明名称 | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide | ||
| 摘要 | A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | ||
| 申请公布号 | US9090571(B2) | 申请公布日期 | 2015.07.28 |
| 申请号 | US201414508185 | 申请日期 | 2014.10.07 |
| 申请人 | TOYAMA CHEMICAL CO., LTD. | 发明人 | Takakura Keiko;Nakamatsu Namika;Takeshima Sakiko;Nakashima Takayoshi |
| 分类号 | C07D241/24;A61K9/00;A61K9/19;A61K31/4965;A61K31/497;A61K47/18;A61K47/22;A61K47/26;A61K9/08 | 主分类号 | C07D241/24 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A process for producing a lyophilized preparation comprising a crystal of a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide, the process comprising: (1) cooling an aqueous solution comprising 6-fluoro-3-hydroxy-2-pyrazinecarboxamide and meglumine to produce a frozen product; (2) increasing the temperature of the frozen product within the range of −20° C to −5° C.; (3) cooling the frozen product again; and (4) carrying out lyophilization. | ||
| 地址 | Tokyo JP | ||