Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

摘要

The present invention provides pharmaceutical compositions for oral administration comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms. The present invention also provides a method for obtaining a reproducible bioavailability of selective factor Xa inhibitor in an object after oral administration comprising orally administering a pharmaceutical composition as described above.

主权项

1. A method for obtaining a reproducible bioavailability of fondaparinux or a pharmaceutically acceptable salt thereof in a subject after oral administration, comprising orally administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of fondaparinux or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid salt and has a carbon chain length of from about 8 to about 14 carbon atoms, and wherein the bioavailability of fondaparinux or a pharmaceutically acceptable salt thereof has a coefficient of variation of no more than about 60%.